Effects of fetal exposure to diazoxide in man.

The acute hemodynamic effects of diazoxide in man.

بررسی اثرات داروی دیازوکساید بر دهلیز مجزای موش صحرایی

Background: It is generally accepted that the selective adenosine triphosphate-dependent potassium channel openers (KATP openers) have a dramatic role in the treatment of some cardiovascular disorders. The aim of this study was to investigate the effects of diazoxide, a potent ATP-related potassium channel opener, on spontaneously beating isolated rat atria to achieve more accurate approaches t...

Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine.

The acute and chronic effects of 20 mM glucose and 10 microM carbachol on beta-cell responses were investigated. Acute exposure of rat islets to 20 mM glucose increased glucose usage rates and resulted in a large insulin-secretory response during a dynamic perifusion. The secretory, but not the metabolic, effect of 20 mM glucose was abolished by simultaneous exposure to 100 microM diazoxide. Gl...

Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats

Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels w...

TRANSLATIONAL PHYSIOLOGY Short-term intermittent exposure to diazoxide improves functional performance of -cells in a high-glucose environment

Yoshikawa, Hiroyasu, Zuheng Ma, Anneli Björklund, and Valdemar Grill. Short-term intermittent exposure to diazoxide improves functional performance of -cells in a high-glucose environment. Am J Physiol Endocrinol Metab 287: E1202–E1208, 2004. First published August 3, 2004; doi:10.1152/ajpendo.00255.2004.—Prolonged periods of “ -cell rest” exert beneficial effects on insulin secretion from panc...